Reconstitution of Distinct Lipoprotein Models, Chylomicron and Disk–High–Density Lipoprotein (Disk–HDL)
نویسندگان
چکیده
منابع مشابه
Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.
Homozygous Watanabe hereditary hyperlipidemic (WHHL) rabbits have a near-complete deficiency of low density lipoprotein (LDL) receptors in liver and other tissues. As a result, these rabbits clear LDL from plasma at an abnormally slow rate. In the current studies we show that WHHL rabbits clear chylomicrons from plasma at a normal rate. Chylomicrons are cleared by a two-step process: (i) hydrol...
متن کاملLipoprotein lip enhances removal of chylomicrons and chylomicron remnants by the perfused rat liver
Lipoprotein lipase has been found to efficiently mediate binding of lipoproteins to cell surfaces and to the low density lipoprotein (LDL) receptor-related protein (LRP) under cell culture conditions (Beisiegel et al. 1991. Proc. Natl. Acad. Sci, USA. 88: 8242-8346). This supports the previously proposed idea that the lipase could have a role in receptor-mediated uptake of chylomicron remnants ...
متن کاملComputational models and methods for lipoprotein research
Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto.fi Author Linda Kumpula Name of the doctoral dissertation Computational models and methods for lipoprotein research Publisher School of Science Unit Dept. of Biomedical Engineering and Computational Science Series Aalto University publication series DOCTORAL DISSERTATIONS 25/2011 Field of research Computational Systems Biology Manuscrip...
متن کاملReconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a).
Lipoprotein(a) (Lp(a)) is an atherosclerosis-causing lipoprotein that circulates in human plasma as a complex of low density lipoprotein (LDL) and apolipoprotein(a) (apo(a)). It is not known whether apo(a) attaches to LDL within hepatocytes prior to secretion or in plasma subsequent to secretion. Here we describe the development of a line of mice expressing the human apo(a) transgene under the ...
متن کاملLipoprotein lipase enhances removal of chylomicrons and chylomicron remnants by the perfused rat liver.
Lipoprotein lipase has been found to efficiently mediate binding of lipoproteins to cell surfaces and to the low density lipoprotein (LDL) receptor-related protein (LRP) under cell culture conditions (Beisiegel et al. 1991. Proc. Natl. Acad. Sci. USA. 88: 8242-8346). This supports the previously proposed idea that the lipase could have a role in receptor-mediated uptake of chylomicron remnants ...
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ژورنال
عنوان ژورنال: MEMBRANE
سال: 2015
ISSN: 0385-1036,1884-6440
DOI: 10.5360/membrane.40.230